DHEA

DHEA

DHEA supplementation has been shown to improve immune system function, aid in weight reduction (thermogenic), support thyroid function, enhance memory and is non-androgenic or estrogenic. The biggest concern over DHEA supplementation is the issue of androgen/estrogen production from DHEA. Various tissues can locally convert DHEA to either androgens (testosterone, dihydrotestosterone, androstenedione) or estrogens (estrone, estradiol). Fortunately, a natural metabolite of DHEA, normally found in the human body, and which cannot be biotransformed into androgens or estrogens, is available called 7-keto DHEA Evidence indicates this “new” DHEA metabolite may be even more potent than DHEA. 7-keto DHEA has been evaluated in both pre-clinical studies and human clinical trials for safety. These studies show no adverse effects for 7-keto DHEA up to doses of 2000 mg /kg in rats and 500 mg /kg in primates. It should be noted that 500 mg /kg is 3.5 grams in a normal 70 kg human which is some 17X my formula dose of .2 grams. Human skin (and other tissues) contains enzymes that convert DHEA to 7-keto DHEA in a two-stage process. (Interestingly, many animal experiments with DHEA get best results if the DHEA is given subcutaneously, hinting at skin DHEA bio-processing.) Research into 7-keto DHEA has been conducted primarily by Dr. Henry Lardy and associates at the University of Wisconsin. Based on his research, Lardy has been granted various patents on the use of 7-keto DHEA, including immune enhancement/modulation, Alzheimer’s treatment and weight loss.

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